A Wordpress widget I use frequently allows the creation of block regions like the BLOX wireframes. You can actually use that widget to create a block region within a block region in which you then place the content blocks. It's a sort of block-ception(to use a portmanteau of block and the movie Inception).
I was trying to create a custom page earlier and I'd love to be able to do the same thing in BLOX I can with Wordpress. I'm calling it BLOXeption. Basically you could create wireframes within the standard BLOX wireframes. This would really open up the ability to customize pages immensely. You would just have to setting determine how each new wireframe collapsed as the screen width changes.
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